ISOLATED ADRENOCORTICOTROPIC HORMONE DEFICIENCY ASSOCIATED WITH SINTILIMAB THERAPY IN A PATIENT WITH ADVANCED LUNG ADENOCARCINOMA: A CASE REPORT AND LITERATURE REVIEW

Abstract Background Several immune checkpoint inhibitors have been implemented for cancer treatment which have shown some degree of antitumor effcacy, while immune-related adverse events (irAEs) that affect multiple organ functions ensue which obviously should not be neglected.Though less common than other kinds of irAEs, Immune checkpoint inhibito

Neurons in the murine vomeronasal organ (VNO) express a family of class Ib major histocompatibility complex (MHC) proteins (M10s) that interact with the V2R class of VNO receptors.This interaction may play a direct role in the detection of pheromonal cues that initiate reproductive and territorial behaviors.The crystal structure of M10.5, an M10 fa